SCHEMBL8557620

SCHEMBL8557620

COc1ccc2cc(CCO)ccc2c1Br

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NCEH1 Q6PIU2 3/20 0.52
CYP19A1 P11511 1/20 0.46
CYP11B1 P15538 1/20 0.46
CYP11B2 P19099 1/20 0.46
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
TSHR P16473 1/20 0.43
NFKB1 P19838 1/20 0.43
LMNA P02545 4/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
APEX1 P27695 1/20 0.42
TUBB4A P04350 2/20 0.41
TUBB P07437 2/20 0.41
TUBA3C P0DPH7 2/20 0.41
TUBA1B P68363 2/20 0.41
TUBA4A P68366 2/20 0.41
TUBB4B P68371 2/20 0.41
TUBB3 Q13509 2/20 0.41
TUBB2A Q13885 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9007503 0.88 NCEH1 (0.48) NCEH1CYP19A1CYP11B1CYP11B2CYP1A2
SCHEMBL6481148 0.83 NCEH1 (0.54) NCEH1CYP19A1CYP1A2CYP3A4LMNA
SCHEMBL9007497 0.83 CYP19A1 (0.49) NCEH1CYP19A1CYP11B1CYP11B2CYP1A2
SCHEMBL4670271 0.81 CYP19A1 (0.48) NCEH1CYP19A1CYP11B1CYP11B2CYP1A2
SCHEMBL11745958 0.79 GAA (0.61) NCEH1CYP19A1CYP11B1CYP11B2TSHR
SCHEMBL4672387 0.79 HTR7 (0.50) NCEH1CYP19A1CYP11B1CYP11B2LMNA
Methane SCHEMBL10453459 0.78 GAA (0.60) NCEH1CYP19A1CYP11B1CYP11B2TSHR
SCHEMBL4673038 0.78 NCEH1 (0.49) NCEH1CYP19A1CYP11B1CYP11B2LMNA
SCHEMBL287146 0.77 MAPT (0.51) CYP1A2CYP3A4TSHRNFKB1LMNA
SCHEMBL9559068 0.77 PDE4A (0.50) CYP19A1CYP1A2CYP3A4TSHRNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0641304-B1 STEREO-SELECTIVE SYNTHESIS OF 2-ARYL-PROPIONIC ACIDS OF HIGH OPTICAL PURITY BY USING CHIRAL OXAZOLINES CHEMISCH BIOTECHNOLOGISCHE LAB (DE) 1998-04-08 EP disclosed
EP-0398288-B1 Process for preparing optically active 2-arylalkanoic acids, in particular 2-arylpropionic acids PUETTER MEDICE CHEM PHARM (DE) 1995-10-18 EP disclosed
EP-0641304-A1 STEREO-SELECTIVE SYNTHESIS OF 2-ARYL-PROPIONIC ACIDS OF HIGH OPTICAL PURITY BY USING CHIRAL OXAZOLINES CHEMISCH BIOTECHNOLOGISCHE LABORATORIEN GMBH (DE) 1995-03-08 EP disclosed
US-5380927-A Process for preparing optically active 2-aryl-alkanoic acids, in particular 2-aryl-propionic acids MEDICE CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1995-01-10 US disclosed
EP-0641304-A4 STEREO-SELECTIVE SYNTHESIS OF 2-ARYL-PROPIONIC ACIDS OF HIGH OPTICAL PURITY BY USING CHIRAL OXAZOLINES. KUNICHEM INC (US) 1994-12-13 EP disclosed
US-5266723-A Process for the preparation of optically active 2-aryl-alkanoic acids, especially 2-aryl-propionic acids MEDICE, LTD., CHEM.-PHARM. FABRIK PUTTER GMBH & CO. KG (DE) 1993-11-30 US disclosed
US-5248815-A STEREO-SELECTIVE SYNTHESIS OF 2-ARYL-PROPIONIC ACIDS OF HIGH OPTICAL PURITY BY USING CHIRAL OXAZOLINES PARADIES HENRICH H (DE) 1993-09-28 US disclosed
WO-1993013046-A1 STEREO-SELECTIVE SYNTHESIS OF 2-ARYL-PROPIONIC ACIDS OF HIGH OPTICAL PURITY BY USING CHIRAL OXAZOLINES KUNICHEM, INC. (US) 1993-07-08 WO disclosed