Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 13/20 | 0.48 |
| ▸ | RARB | P10826 | 13/20 | 0.48 |
| ▸ | RARG | P13631 | 13/20 | 0.48 |
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6705630 | 1.00 | RARA (0.48) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL7051352 | 0.87 | RARA (0.48) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6294022 | 0.83 | RARA (0.69) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6294021 | 0.83 | RARA (0.69) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8559149 | 0.80 | RARA (0.32) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8559151 | 0.80 | RARA (0.32) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6297113 | 0.80 | GAA (0.32) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8331911 | 0.79 | RARB (0.63) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8560231 | 0.79 | RARA (0.50) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8560234 | 0.79 | RARA (0.50) | RARARARBRARGRXRANR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5808124-A | BINDING TO RETINOID RECEPTORS | ALLERGAN (US) | 1998-09-15 | — | — | US | disclosed |
| US-5773594-A | TREATING SKIN DISORDERS, REDUCING SIDE EFFECTS OF OTHER RETINOIDS | ALLERGAN (US) | 1998-06-30 | — | — | US | disclosed |
| US-5763635-A | Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity | ALLERGAN (US) | 1998-06-09 | — | — | US | disclosed |
| US-5747542-A | SKIN DISORDERS; ANTICANCER AGENTS | ALLERGAN (US) | 1998-05-05 | — | — | US | disclosed |
| US-5741896-A | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity | ALLERGAN (US) | 1998-04-21 | — | — | US | disclosed |
| US-5723666-A | USEFUL AS REGULATORS OF CELL PROLIFERATION AND DIFFERENTIATION | ALLERGAN (US) | 1998-03-03 | — | — | US | disclosed |