Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 14/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | CTSV | O60911 | 1/20 | 0.35 |
| ▸ | CTSL | P07711 | 1/20 | 0.35 |
| ▸ | CTSB | P07858 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561114 | 0.90 | TACR1 (0.40) | TACR1GHSR | |
| SCHEMBL8559324 | 0.90 | KCNA5 (0.38) | TACR1CTSSCTSLKCNA5 | |
| SCHEMBL8559848 | 0.89 | TACR1 (0.40) | TACR1 | |
| Hydrochloric Acid SCHEMBL8563552 | 0.89 | KCNA5 (0.38) | TACR1CTSSCTSLKCNA5 | |
| SCHEMBL8561651 | 0.89 | TACR1 (0.42) | TACR1GHSR | |
| SCHEMBL8563529 | 0.87 | TACR1 (0.41) | TACR1 | |
| SCHEMBL8559389 | 0.87 | TACR1 (0.42) | TACR1CTSSCTSLGHSR | |
| SCHEMBL8559555 | 0.87 | TACR1 (0.40) | TACR1GHSR | |
| SCHEMBL8559045 | 0.86 | TACR1 (0.41) | TACR1CTSB | |
| SCHEMBL8560138 | 0.86 | TACR1 (0.41) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811431-A | Spiro-substituted azacyclic derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 1998-09-22 | — | — | US | disclosed |