Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 16/20 | 0.40 |
| ▸ | UGCG | Q16739 | 3/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559848 | 0.95 | TACR1 (0.40) | TACR1UGCG | |
| SCHEMBL8559045 | 0.93 | TACR1 (0.41) | TACR1UGCGCYP3A4 | |
| SCHEMBL8560138 | 0.93 | TACR1 (0.41) | TACR1UGCGCYP3A4 | |
| SCHEMBL8559555 | 0.93 | TACR1 (0.40) | TACR1GHSR | |
| SCHEMBL8561651 | 0.90 | TACR1 (0.42) | TACR1GHSR | |
| SCHEMBL8557797 | 0.90 | TACR1 (0.35) | TACR1GHSR | |
| SCHEMBL8563536 | 0.90 | TACR1 (0.45) | TACR1UGCGGHSRCYP3A4 | |
| SCHEMBL8566409 | 0.89 | TACR1 (0.53) | TACR1 | |
| SCHEMBL8564711 | 0.89 | TACR1 (0.43) | TACR1UGCGGHSRCYP3A4 | |
| SCHEMBL8807964 | 0.88 | TACR1 (0.41) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811431-A | Spiro-substituted azacyclic derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 1998-09-22 | — | — | US | disclosed |