Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 12/20 | 0.75 |
| ▸ | ATF1 | P18846 | 9/20 | 0.75 |
| ▸ | XPO1 | O14980 | 5/20 | 0.61 |
| ▸ | JUN | P05412 | 4/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.61 |
| ▸ | RELA | Q04206 | 4/20 | 0.61 |
| ▸ | CNR2 | P34972 | 4/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8542065 | 0.84 | ATF1 (0.69) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL541685 | 0.81 | NFKB1 (0.65) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL458841 | 0.76 | NFKB1 (1.00) | NFKB1ATF1XPO1JUNNFKB2 | |
| SCHEMBL3381215 | 0.76 | CNR2 (0.60) | NFKB1ATF1CNR2CYP3A4CYP2D6 | |
| SCHEMBL5083067 | 0.73 | GAA (0.57) | NFKB1ATF1CNR2CYP3A4CYP2D6 | |
| SCHEMBL3379898 | 0.73 | CNR2 (0.64) | NFKB1ATF1CNR2CYP3A4CYP2D6 | |
| SCHEMBL3380654 | 0.73 | CNR2 (0.64) | NFKB1ATF1CNR2CYP3A4CYP2D6 | |
| SCHEMBL6475927 | 0.72 | MAPT (0.60) | NFKB1ATF1JUNNFKB2RELA | |
| SCHEMBL5083338 | 0.71 | CNR2 (0.85) | CNR2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL3379458 | 0.71 | CNR2 (0.84) | CNR2CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811428-A | ADMINISTERING FOR THE TREATMENT AND PREVENTION OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-22 | — | — | US | claimed |
| US-5811428-A | ADMINISTERING FOR THE TREATMENT AND PREVENTION OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES | SIGNAL PHARMACEUTICALS, INC. (US) | 1998-09-22 | — | — | US | disclosed |