Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | FBP1 | P09467 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5397061 | 0.79 | CYP1A2 (0.60) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL2590963 | 0.77 | ALDH1A1 (0.66) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL14726501 | 0.77 | ALDH1A1 (0.76) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL11872214 | 0.76 | CYP1A2 (1.00) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL330441 | 0.76 | CYP1A2 (0.72) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL8558456 | 0.75 | ALDH1A1 (0.68) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL28620714 | 0.75 | CYP1A2 (0.62) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL10475629 | 0.75 | ALDH1A1 (0.71) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL12495533 | 0.74 | ALDH1A1 (0.66) | ALDH1A1GAAPOLBCYP1A2MAPT | |
| SCHEMBL7270583 | 0.74 | ALDH1A1 (0.66) | ALDH1A1GAAPOLBCYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0518731-B1 | 2-(Indol-2-yl-carbonylamino)-thiazole derivatives, their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-08-26 | — | — | EP | disclosed |
| US-5380736-A | Cholecystokinin and gastric antagonist | ELF SANOFI (FR) | 1995-01-10 | — | — | US | disclosed |
| US-5314889-A | Hormone antagonists | ELF SANOFI (FR) | 1994-05-24 | — | — | US | disclosed |
| EP-0518731-A1 | Heterocyclic derivatives of substituted 2-acylamino 5-thiazole, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1992-12-16 | — | — | EP | disclosed |