Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.46 |
| ▸ | RXRB | P28702 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 8/20 | 0.46 |
| ▸ | RARG | P13631 | 8/20 | 0.46 |
| ▸ | RARA | P10276 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.46 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 7/20 | 0.43 |
| ▸ | TACR2 | P21452 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106331 | 0.84 | RXRA (0.60) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8558683 | 0.81 | CYP3A4 (0.45) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8558461 | 0.81 | RXRA (0.47) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8557720 | 0.76 | RARB (0.48) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8555829 | 0.75 | RARB (0.48) | RXRARXRBRARBRARGRARA | |
| SCHEMBL7762896 | 0.73 | RXRA (0.65) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8108587 | 0.73 | RXRA (0.53) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8100967 | 0.73 | RXRA (0.64) | RXRARXRBRARBRARGRARA | |
| SCHEMBL8108641 | 0.73 | CYP3A4 (0.45) | RXRARXRBRARBRARGRARA | |
| SCHEMBL10459874 | 0.72 | RXRA (0.64) | RXRARXRBRARBRARGRARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | claimed |
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |