Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11619194 | 0.95 | DRD2 (0.46) | DRD2HCRTR2KDM4ELTA4H | |
| SCHEMBL11263811 | 0.90 | HCRTR2 (0.41) | DRD2SPHK1HCRTR2PPARG | |
| SCHEMBL11254714 | 0.90 | HCRTR2 (0.41) | DRD2SPHK1HCRTR2PPARG | |
| SCHEMBL11263813 | 0.90 | HCRTR2 (0.41) | DRD2SPHK1HCRTR2PPARG | |
| SCHEMBL11254705 | 0.90 | HCRTR2 (0.41) | DRD2SPHK1HCRTR2PPARG | |
| SCHEMBL26941799 | 0.88 | DRD2 (0.49) | DRD2HCRTR2KDM4E | |
| SCHEMBL11260150 | 0.87 | HCRTR2 (0.42) | DRD2HCRTR2 | |
| SCHEMBL11260153 | 0.87 | HCRTR2 (0.42) | DRD2HCRTR2 | |
| SCHEMBL14618505 | 0.86 | SPHK1 (0.43) | SPHK1 | |
| SCHEMBL10938939 | 0.86 | SPHK1 (0.40) | SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757669-B1 | O-ACYL-4-PHENYL-CYCLOHEXANOLS, THEIR SALTS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE, AS WELL AS A METHOD OF PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1998-11-18 | — | — | EP | claimed |
| US-5962507-A | BLOCKING CHOLESTEROL BIOSYNTHESIS | DR. KARL THOMAE GMBH (DE) | 1999-10-05 | — | — | US | disclosed |
| US-5962507-A | BLOCKING CHOLESTEROL BIOSYNTHESIS | DR. KARL THOMAE GMBH (DE) | 1999-10-05 | — | — | US | disclosed |
| EP-0757669-B1 | O-ACYL-4-PHENYL-CYCLOHEXANOLS, THEIR SALTS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE, AS WELL AS A METHOD OF PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1998-11-18 | — | — | EP | disclosed |
| US-5726205-A | ANTICHOLESTEROL AGENTS | KARL THOMAE GMBH (DE) | 1998-03-10 | — | — | US | disclosed |
| CN-1147809-A | 0-acyl-4-phenyl-cyclohexanols, their salts, medicaments containing such compounds and their use, as well as a method of preparing them | THOMAE GMBH DR K (DE) | 1997-04-16 | — | — | CN | disclosed |
| EP-0757669-A1 | O-ACYL-4-PHENYL-CYCLOHEXANOLS, THEIR SALTS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE, AS WELL AS A METHOD OF PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-02-12 | — | — | EP | disclosed |
| WO-1995029148-A1 | O-ACYL-4-PHENYL-CYCLOHEXANOLS, THEIR SALTS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE, AS WELL AS A METHOD OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1995-11-02 | — | — | WO | disclosed |