Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558041 | 1.00 | ALOX5 (0.48) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL2108382 | 1.00 | ALOX5 (0.48) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL2109207 | 0.86 | ALOX5 (0.49) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL2108142 | 0.85 | ALOX5 (0.51) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL2107548 | 0.83 | ALOX5 (0.43) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL8556671 | 0.81 | MAP2K1 (0.32) | — | |
| SCHEMBL8557662 | 0.80 | ALOX5 (0.47) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL8554154 | 0.79 | BRD4 (0.38) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL1445371 | 0.78 | ALOX5 (0.41) | ALOX5TRIM24CREBBP | |
| SCHEMBL7608078 | 0.78 | ALOX5 (0.41) | ALOX5TRIM24CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |