Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558163 | 1.00 | MAPT (0.33) | MAPTHPGDALDH1A1TSHRBRD4 | |
| SCHEMBL8558157 | 1.00 | MAPT (0.33) | MAPTHPGDALDH1A1TSHRBRD4 | |
| SCHEMBL8556516 | 0.90 | NPSR1 (0.34) | MAPTHPGDALDH1A1TSHRBRD4 | |
| SCHEMBL8556519 | 0.90 | NPSR1 (0.34) | MAPTHPGDALDH1A1TSHRBRD4 | |
| SCHEMBL8557790 | 0.90 | NPSR1 (0.34) | MAPTHPGDALDH1A1TSHRBRD4 | |
| SCHEMBL8558931 | 0.89 | MAPT (0.32) | MAPTHPGDALDH1A1TSHRBRD4 | |
| SCHEMBL8555109 | 0.80 | EPHX2 (0.34) | MAPTHPGDALDH1A1TSHRBRD4 | |
| SCHEMBL8557886 | 0.79 | HCRTR2 (0.38) | MAPTHPGDALDH1A1TSHRBRD4 | |
| SCHEMBL8554401 | 0.79 | HCRTR2 (0.38) | MAPTHPGDALDH1A1TSHRBRD4 | |
| SCHEMBL8554399 | 0.79 | HCRTR2 (0.38) | MAPTHPGDALDH1A1TSHRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |