Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 11/20 | 0.52 |
| ▸ | BCL2 | P10415 | 8/20 | 0.47 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556189 | 0.86 | MCL1 (0.49) | MCL1BCL2BCL2L1HTR2AHTR2C | |
| SCHEMBL17686343 | 0.79 | MCL1 (0.54) | MCL1BCL2BCL2L1LIPGMAPT | |
| SCHEMBL17686345 | 0.75 | MCL1 (0.56) | MCL1BCL2BCL2L1LIPGMAPT | |
| SCHEMBL8559870 | 0.74 | HTR2A (0.76) | MCL1BCL2BCL2L1HTR2AHTR2C | |
| SCHEMBL17686337 | 0.69 | MCL1 (0.70) | MCL1BCL2BCL2L1 | |
| SCHEMBL17686302 | 0.66 | MCL1 (0.53) | MCL1BCL2BCL2L1MAPTLMNA | |
| SCHEMBL17686308 | 0.65 | MCL1 (1.00) | MCL1BCL2BCL2L1 | |
| SCHEMBL8700039 | 0.64 | KDM4E (0.67) | MCL1BCL2BCL2L1LMNA | |
| SCHEMBL11485653 | 0.63 | MCL1 (0.50) | MCL1BCL2BCL2L1HTR2AMAPT | |
| SCHEMBL8137309 | 0.63 | MCL1 (0.50) | MCL1BCL2BCL2L1LIPGMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529452-B1 | 1,7-Condensed 3-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SOLVAY PHARM GMBH (DE) | 1998-11-11 | — | — | EP | disclosed |
| US-5324725-A | Antiinflammatory agent, antiallergen | KALI-CHEMIE PHARMA GMBH (DE) | 1994-06-28 | — | — | US | disclosed |
| EP-0529452-A2 | 1,7-Condensed 2-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | Kali-Chemie Pharma GmbH (DE) | 1993-03-03 | — | — | EP | disclosed |