Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 10/20 | 0.50 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.38 |
| ▸ | BCL2 | P10415 | 7/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30556066 | 0.74 | LMNA (0.35) | MCL1LIPGTP53LMNA | |
| SCHEMBL29947861 | 0.73 | ADRB2 (0.33) | MCL1 | |
| SCHEMBL23540521 | 0.73 | ADRB2 (0.33) | MCL1 | |
| SCHEMBL6999859 | 0.73 | KMT2A (0.50) | MCL1MAPTLMNAPOLBTDP1 | |
| SCHEMBL29654386 | 0.72 | HDAC8 (0.33) | — | |
| SCHEMBL23540663 | 0.72 | HDAC8 (0.33) | — | |
| SCHEMBL9586314 | 0.71 | MCL1 (0.46) | MCL1LIPGBCL2L1BCL2MAPT | |
| SCHEMBL7005388 | 0.71 | HPGD (0.55) | MCL1LMNAPOLB | |
| SCHEMBL7005451 | 0.71 | HTR3A (0.36) | MAPTLMNATDP1 | |
| SCHEMBL7004582 | 0.70 | HPGD (0.50) | MCL1LIPGLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023183755-A1 | TRICYCLIC PYRIMIDONES | ERASCA, INC. (US) | 2023-09-28 | — | — | WO | disclosed |
| WO-2022265974-A1 | AMINOHETEROCYCLE-SUBSTITUTED TRICYCLIC KRAS INHIBITORS | ERASCA, INC. (US) | 2022-12-22 | — | — | WO | disclosed |
| EP-1028950-A1 | NOVEL 7-SUBSTITUTED QUINAZOLIN-2,4-DIONES USEFUL AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999021840-A1 | NOVEL 7-SUBSTITUTED QUINAZOLIN-2,4-DIONES USEFUL AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1999-05-06 | — | — | WO | disclosed |