Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.48 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8564983 | 0.89 | AVPR2 (0.56) | AVPR2AVPR1A | |
| SCHEMBL8559574 | 0.88 | AVPR1A (0.56) | AVPR2AVPR1A | |
| SCHEMBL8561578 | 0.87 | AVPR1A (0.55) | NPC1TP53RAB9ASMN1; SMN2AVPR2 | |
| SCHEMBL8565042 | 0.87 | AVPR2 (0.62) | NPC1RAB9AAVPR2AVPR1A | |
| SCHEMBL8559608 | 0.86 | AVPR2 (0.49) | AVPR2AVPR1A | |
| SCHEMBL8559404 | 0.86 | AVPR2 (0.49) | AVPR2AVPR1A | |
| SCHEMBL8561595 | 0.83 | ACHE (0.61) | ACHEAVPR2AVPR1A | |
| SCHEMBL8556495 | 0.83 | AVPR2 (0.55) | AVPR2AVPR1A | |
| SCHEMBL8557743 | 0.79 | AVPR2 (0.64) | ACHEAVPR2AVPR1A | |
| SCHEMBL8557374 | 0.78 | AVPR2 (0.58) | ACHEAVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |