Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 4/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.51 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | SLCO1B3 | Q9NPD5 | 2/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566614 | 0.91 | AGTR2 (0.63) | AGTR2CYP3A4AGTR1PDE3AABCB11 | |
| SCHEMBL15702899 | 0.90 | AGTR2 (0.74) | AGTR2CYP3A4AGTR1PDE3AABCB11 | |
| SCHEMBL15156867 | 0.89 | AGTR2 (0.73) | AGTR2CYP3A4AGTR1PDE3AABCB11 | |
| SCHEMBL15171199 | 0.89 | AGTR2 (0.73) | AGTR2CYP3A4AGTR1PDE3AABCB11 | |
| SCHEMBL15156864 | 0.89 | AGTR2 (0.73) | AGTR2CYP3A4AGTR1PDE3AABCB11 | |
| SCHEMBL15644523 | 0.88 | AGTR2 (0.78) | AGTR2CYP3A4AGTR1PDE3AABCB11 | |
| SCHEMBL15551977 | 0.87 | AGTR2 (0.71) | AGTR2CYP3A4AGTR1PDE3AABCB11 | |
| SCHEMBL15157278 | 0.87 | AGTR2 (0.71) | AGTR2CYP3A4AGTR1PDE3AABCB11 | |
| Azilsartan Medoxomil SCHEMBL2129551 | 0.87 | AGTR2 (0.81) | AGTR2CYP3A4AGTR1PDE3AABCB11 | |
| Azilsartan Medoxomil SCHEMBL29861385 | 0.86 | AGTR2 (1.00) | AGTR2CYP3A4AGTR1PDE3AABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | claimed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | claimed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | claimed |
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |