Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 5/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559082 | 0.84 | ADORA1 (0.62) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL8563869 | 0.82 | ADORA1 (0.47) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| 1,3-Dipropyl-8-Cyclopentylxanthine [Dpcpx] SCHEMBL12648692 | 0.77 | ADORA1 (0.67) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL8361054 | 0.74 | ADORA1 (0.47) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL7003429 | 0.66 | ADORA1 (0.58) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL8563874 | 0.66 | ADORA1 (0.64) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL8559224 | 0.65 | ADORA1 (0.61) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| 8-Cyclopentyltheophylline SCHEMBL18029489 | 0.65 | ADORA2A (0.61) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL18083845 | 0.64 | ADORA1 (0.69) | ADORA2BADORA1ADORA2AADORA3MEN1 | |
| SCHEMBL7661349 | 0.64 | ADORA2A (0.58) | ADORA2BADORA1ADORA2AADORA3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0880524-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | Boehringer Ingelheim Pharma KG (DE) | 1998-12-02 | — | — | EP | disclosed |
| WO-1998003511-A1 | NEW TRIAZOLOPURINES, METHOD OF PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 1998-01-29 | — | — | WO | disclosed |