Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 6/20 | 0.58 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.58 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002301 | 0.92 | ADORA1 (0.61) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL7661349 | 0.85 | ADORA2A (0.58) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL6998057 | 0.85 | ADORA1 (0.58) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL7656557 | 0.85 | ADORA3 (0.58) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL6997855 | 0.83 | ADORA1 (0.55) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL7000539 | 0.82 | ADORA1 (0.54) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL7668320 | 0.81 | ADORA1 (0.53) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL7668693 | 0.81 | ADORA1 (0.51) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL6998913 | 0.80 | ADORA1 (0.52) | ADORA1ADORA2AADORA2BADORA3LMNA | |
| SCHEMBL7662113 | 0.79 | ADORA1 (0.51) | ADORA1ADORA2AADORA2BADORA3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087973-B1 | IMIDAZOTRIAZOLOPYRIMIDINES USED AS A DRUG HAVING AN ADENOSINE ANTAGONIST ACTIVITY | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-01-08 | — | — | EP | disclosed |
| US-6492377-B1 | Imidazotriazolopyrimidines with adenosine-antagonistic activity | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-12-10 | — | — | US | disclosed |