Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 9/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 9/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8565651 | 0.99 | UTS2R (0.43) | UTS2ROPRK1ALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL8562893 | 0.89 | UTS2R (0.54) | UTS2ROPRK1HCRTR1HCRTR2CYP3A4 | |
| Hydrochloric Acid SCHEMBL8561921 | 0.88 | UTS2R (0.53) | UTS2ROPRK1HCRTR1HCRTR2CYP3A4 | |
| SCHEMBL8561415 | 0.86 | HRH3 (0.43) | OPRK1CYP3A4 | |
| SCHEMBL8558296 | 0.86 | OPRK1 (0.48) | UTS2ROPRK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8558540 | 0.85 | OPRK1 (0.48) | UTS2ROPRK1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8557411 | 0.85 | OPRK1 (0.43) | OPRK1CYP3A4 | |
| SCHEMBL8562223 | 0.84 | UTS2R (0.46) | UTS2ROPRK1CYP3A4 | |
| Hydrochloric Acid SCHEMBL8560223 | 0.84 | UTS2R (0.46) | UTS2ROPRK1CYP3A4 | |
| SCHEMBL8562812 | 0.84 | OPRK1 (0.40) | OPRK1CYP3A4THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |