Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.33 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11386324 | 0.86 | P2RX4 (0.37) | MAPTP2RX4TSHRSMN1; SMN2LMNA | |
| SCHEMBL4698118 | 0.81 | KDM4E (0.43) | MAPTCYP1A2TSHRCYP2C19SMN1; SMN2 | |
| SCHEMBL3250625 | 0.79 | MAPT (0.40) | MAPTP2RX4HSD17B10TSHRSMN1; SMN2 | |
| SCHEMBL14921032 | 0.75 | EPHX2 (0.36) | MAPTP2RX4SMN1; SMN2LMNAGAA | |
| SCHEMBL30805659 | 0.75 | EPHX2 (0.36) | MAPTP2RX4SMN1; SMN2LMNAGAA | |
| SCHEMBL28219643 | 0.73 | FABP7 (0.43) | P2RX4TSHRLMNAALDH1A1 | |
| SCHEMBL385982 | 0.72 | MAPT (0.40) | MAPTP2RX4HSD17B10CYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL7435031 | 0.70 | MAPT (0.39) | MAPTP2RX4HSD17B10CYP3A4CYP2C9 | |
| SCHEMBL1286805 | 0.70 | MAPT (0.38) | MAPTP2RX4TSHRSMN1; SMN2LMNA | |
| SCHEMBL31301236 | 0.70 | MAPT (0.38) | MAPTP2RX4TSHRSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756739-A | Process for preparing polyamine derivative and intermediates thereof | MERRELL PHARMACEUTICALS INC. (US) | 1998-05-26 | — | — | US | disclosed |
| US-4207322-A | 6-Aryl-s-triazolo-(4,3-alpha)-pyrido-(2,3-f)-(1,4)-diazepines | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1980-06-10 | — | — | US | disclosed |
| US-4110455-A | 6-ARYL-S-TRIAZOLO-(4,3-A)-PYRIDO-(2,3-F)-1,4-DIAZEPINES | DEUTSCHE GOLD- UND SILBER-SCHEIDEANSTALT VORMALS ROESSLER (DE) | 1978-08-29 | — | — | US | disclosed |