Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562664 | 0.94 | CRBN (0.44) | HRH3KCNH2SIGMAR1CRBNOPRK1 | |
| SCHEMBL8559421 | 0.86 | OPRK1 (0.41) | HRH3KCNH2OPRK1 | |
| SCHEMBL8562495 | 0.85 | FNTA (0.41) | HRH3OPRK1 | |
| SCHEMBL8563922 | 0.85 | HRH3 (0.57) | HRH3KCNH2KCNQ2 | |
| Hydrochloric Acid SCHEMBL8561384 | 0.84 | HRH3 (0.56) | HRH3KCNH2SIGMAR1OPRK1 | |
| SCHEMBL8558938 | 0.83 | OPRK1 (0.42) | SIGMAR1OPRK1OPRD1 | |
| Hydrochloric Acid SCHEMBL8556994 | 0.82 | OPRK1 (0.42) | SIGMAR1OPRK1OPRD1 | |
| SCHEMBL8561606 | 0.80 | FNTA (0.40) | HRH3OPRK1 | |
| SCHEMBL8559582 | 0.80 | HRH3 (0.44) | HRH3KCNH2KCNQ2CRBNOPRK1 | |
| SCHEMBL8563983 | 0.79 | OPRK1 (0.48) | HRH3KCNH2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |