SCHEMBL8559728

SCHEMBL8559728

NC1CCN(c2c(F)cc3c(=O)c(C(=O)O)c[nH]c3c2C2(Cl)CC2)C1

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.52
POLB P06746 1/20 0.52
CHRM2 P08172 1/20 0.52
CHRM1 P11229 1/20 0.52
OPRM1 P35372 1/20 0.52
OPRD1 P41143 1/20 0.52
TOP2A P11388 13/20 0.46
TOP2B Q02880 10/20 0.46
PIM3 Q86V86 2/20 0.44
RPS6KB1 P23443 1/20 0.44
MATK P42679 1/20 0.44
DYRK1A Q13627 1/20 0.44
MAPKAPK3 Q16644 1/20 0.44
AURKB Q96GD4 1/20 0.44
TOP1 P11387 5/20 0.44
PIM1 P11309 1/20 0.42
GSK3A P49840 1/20 0.42
GSK3B P49841 1/20 0.42
CSNK1G1 Q9HCP0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8564292 0.99 ALDH1A1 (0.51) ALDH1A1POLBCHRM2CHRM1OPRM1
Hydrochloric Acid SCHEMBL2915199 0.93 ALDH1A1 (0.45) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL9537686 0.87 KCNH2 (0.58) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL10751705 0.84 ALDH1A1 (0.38) ALDH1A1POLBCHRM2CHRM1OPRM1
Hydrochloric Acid SCHEMBL10914785 0.84 ALDH1A1 (0.55) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL5671617 0.84 ALDH1A1 (0.37) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL9536726 0.84 KCNH2 (0.49) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL10866859 0.84 KCNH2 (0.41) ALDH1A1POLBCHRM2CHRM1OPRM1
Hydrochloric Acid SCHEMBL10862782 0.84 KCNH2 (0.41) ALDH1A1POLBCHRM2CHRM1OPRM1
SCHEMBL9539400 0.84 KCNH2 (0.47) ALDH1A1POLBCHRM2CHRM1OPRM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828714-A1 METHOD FOR MAKING QUINOLONE CARBOXYLIC ACIDS OR NAPHTHYRIDINE CARBOXYLIC ACIDS IN FREE BASE FORM WARNER-LAMBERT COMPANY (US) 1998-03-18 EP claimed
WO-1996037475-A1 METHOD FOR MAKING QUINOLONE CARBOXYLIC ACIDS OR NAPHTHYRIDINE CARBOXYLIC ACIDS IN FREE BASE FORM WARNER-LAMBERT COMPANY (US) 1996-11-28 WO claimed
EP-0666743-A1 SOLUBLE CALCIUM LACTATE/QUINDONECARBOXYLIC ACIDS ON NAPHTHYDRINECARBOXYLIC ACIDS COMPLEXES AS NON-IRRITATING PARENTERAL FORMS WARNER-LAMBERT COMPANY (US) 1995-08-16 EP claimed
WO-1994009779-A1 SOLUBLE CALCIUM LACTATE/QUINDONECARBOXYLIC ACIDS ON NAPHTHYDRINECARBOXYLIC ACIDS COMPLEXES AS NON-IRRITATING PARENTERAL FORMS WARNER-LAMBERT COMPANY (US) 1994-05-11 WO claimed
EP-0828714-A1 METHOD FOR MAKING QUINOLONE CARBOXYLIC ACIDS OR NAPHTHYRIDINE CARBOXYLIC ACIDS IN FREE BASE FORM WARNER-LAMBERT COMPANY (US) 1998-03-18 EP disclosed
WO-1996037475-A1 METHOD FOR MAKING QUINOLONE CARBOXYLIC ACIDS OR NAPHTHYRIDINE CARBOXYLIC ACIDS IN FREE BASE FORM WARNER-LAMBERT COMPANY (US) 1996-11-28 WO disclosed
EP-0195316-A1 Quinolonecarboxylic acid derivatives KYORIN PHARMACEUTICAL CO., LTD. (JP) 1986-09-24 EP disclosed