Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.85 |
| ▸ | NPC1 | O15118 | 1/20 | 0.85 |
| ▸ | CASP3 | P42574 | 1/20 | 0.85 |
| ▸ | RAB9A | P51151 | 1/20 | 0.85 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.85 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.85 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.85 |
| ▸ | DPP4 | P27487 | 1/20 | 0.77 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.69 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.69 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.69 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.69 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.69 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.69 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.69 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9242650 | 1.00 | TDP1 (0.85) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL7426101 | 1.00 | TDP1 (0.85) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL3070677 | 0.98 | TDP1 (0.89) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL839278 | 0.92 | TDP1 (1.00) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL27463271 | 0.91 | DPP4 (0.81) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL8894978 | 0.88 | MAPT (0.74) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL8519287 | 0.88 | TDP1 (1.00) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL27516050 | 0.88 | TDP1 (1.00) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL9057671 | 0.88 | TDP1 (1.00) | TDP1NPC1CASP3RAB9ASENP8 | |
| SCHEMBL27545788 | 0.86 | TDP1 (0.69) | TDP1NPC1CASP3RAB9ASENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843997-A | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5576323-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| CN-1108240-A | Excitatory amino acid receptor antagonists | LILLY CO ELI (US) | 1995-09-13 | — | — | CN | disclosed |
| EP-0658539-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1995-06-21 | — | — | EP | disclosed |