SCHEMBL8559946

SCHEMBL8559946

CC(=O)NN(C(C)=O)c1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Cl)c(C)nc34)c2Cl)cc1

nearest known ligand 0.76

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8565394 0.99 BDKRB2 (0.76) BDKRB2
SCHEMBL8565049 0.94 BDKRB2 (0.87) BDKRB2
Hydrochloric Acid SCHEMBL8563034 0.93 BDKRB2 (0.87) BDKRB2
SCHEMBL8560082 0.90 BDKRB2 (0.77) BDKRB2
Hydrochloric Acid SCHEMBL8567353 0.90 BDKRB2 (0.77) BDKRB2
SCHEMBL8567472 0.90 BDKRB2 (0.88) BDKRB2
SCHEMBL8567475 0.90 BDKRB2 (0.88) BDKRB2
Hydrochloric Acid SCHEMBL8564959 0.89 BDKRB2 (0.88) BDKRB2
Hydrochloric Acid SCHEMBL8564960 0.89 BDKRB2 (0.88) BDKRB2
SCHEMBL8561972 0.89 BDKRB2 (0.75) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed