Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 5/20 | 0.52 |
| ▸ | JAK2 | O60674 | 4/20 | 0.52 |
| ▸ | JAK1 | P23458 | 3/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 2/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8473992 | 0.78 | PARP1 (0.51) | TYK2JAK2JAK1PTGESPARP1 | |
| SCHEMBL13135977 | 0.78 | PARP1 (0.51) | HDAC3BRD4HDAC4HDAC1HDAC7 | |
| SCHEMBL27660069 | 0.78 | PARP1 (0.59) | HDAC3BRD4HDAC4HDAC1HDAC7 | |
| SCHEMBL27888402 | 0.78 | PARP1 (0.59) | HDAC3BRD4HDAC4HDAC1HDAC7 | |
| SCHEMBL24534325 | 0.77 | HDAC3 (0.50) | HDAC3BRD4HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL28155445 | 0.77 | PARP1 (0.58) | HDAC3BRD4HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL27660077 | 0.77 | PARP1 (0.58) | HDAC3BRD4HDAC4HDAC1HDAC7 | |
| SCHEMBL196738 | 0.77 | PARP1 (0.56) | JAK2BRD4PARP1MEN1KMT2A | |
| SCHEMBL8569632 | 0.76 | TRPV1 (0.58) | TYK2JAK2JAK1PTGESCYP3A4 | |
| SCHEMBL8597761 | 0.76 | PTGES (0.52) | TYK2JAK2JAK1PTGESMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863881-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997010219-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE IN THE PREVENTION AND/OR THE TREATMENT OF BONE DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-03-20 | — | — | WO | disclosed |