Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 11/20 | 0.47 |
| ▸ | PPARG | P37231 | 10/20 | 0.47 |
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565717 | 0.90 | TSHR (0.42) | PPARAPPARGMEN1LMNAKMT2A | |
| SCHEMBL1311165 | 0.83 | ACE (0.59) | PPARAPPARGACEPPARDITGB3 | |
| SCHEMBL1529592 | 0.83 | ACE (0.59) | PPARAPPARGACEPPARDITGB3 | |
| SCHEMBL1748947 | 0.83 | ACE (0.59) | PPARAPPARGACEPPARDITGB3 | |
| SCHEMBL26932496 | 0.83 | PPARA (0.57) | PPARAPPARGACEPPARDCTSL | |
| SCHEMBL556571 | 0.83 | PPARA (0.57) | PPARAPPARGACEPPARDCTSL | |
| SCHEMBL29866102 | 0.83 | PPARA (0.57) | PPARAPPARGACEPPARDCTSL | |
| SCHEMBL8562043 | 0.81 | PPARA (0.51) | PPARAPPARGACEPPARDCTSS | |
| SCHEMBL8335300 | 0.80 | PPARA (0.68) | PPARAPPARGACEPPARDITGB3 | |
| SCHEMBL8335293 | 0.80 | PPARA (0.68) | PPARAPPARGACEPPARDITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811431-A | Spiro-substituted azacyclic derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 1998-09-22 | — | — | US | disclosed |
| EP-0775140-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LTD. (GB) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996005203-A1 | SPIRO-SUBSTITUTED AZACYCLIC DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | MERCK SHARP & DOHME LIMITED (GB) | 1996-02-22 | — | — | WO | disclosed |