Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560370 | 0.90 | PPARA (0.47) | TSHRMEN1LMNAKMT2APPARA | |
| SCHEMBL30703902 | 0.83 | PSEN1 (0.54) | KLK5PPARAPPARGPSEN1PSEN2 | |
| SCHEMBL8560272 | 0.81 | PSEN1 (0.46) | KLK5PPARAPPARGPSEN1PSEN2 | |
| SCHEMBL8559055 | 0.80 | TSHR (0.50) | TSHRKLK5LMNAPPARAPPARG | |
| SCHEMBL29839160 | 0.77 | CTSL (0.48) | TSHRPPARAPPARGCTSLTACR1 | |
| SCHEMBL27228870 | 0.77 | CTSL (0.48) | TSHRPPARAPPARGCTSLTACR1 | |
| SCHEMBL27228877 | 0.77 | CTSL (0.48) | TSHRPPARAPPARGCTSLTACR1 | |
| SCHEMBL27232298 | 0.77 | CTSL (0.48) | TSHRPPARAPPARGCTSLTACR1 | |
| SCHEMBL18130491 | 0.76 | MEN1 (0.48) | TSHRMEN1LMNAKMT2APPARA | |
| SCHEMBL1311165 | 0.76 | ACE (0.59) | PPARAPPARGCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5811431-A | Spiro-substituted azacyclic derivatives and their use as therapeutic agents | MERCK SHARP & DOHME LTD. (GB) | 1998-09-22 | — | — | US | disclosed |