Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 7/20 | 0.73 |
| ▸ | EGFR | P00533 | 11/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.59 |
| ▸ | ABL1 | P00519 | 3/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.58 |
| ▸ | SRC | P12931 | 3/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8894449 | 0.99 | ERBB2 (0.72) | ERBB2EGFRERBB4ABL1PDGFRB | |
| SCHEMBL8554934 | 0.85 | ERBB2 (1.00) | ERBB2EGFRERBB4ABL1 | |
| SCHEMBL31061496 | 0.85 | ERBB2 (1.00) | ERBB2EGFRERBB4ABL1 | |
| Hydrochloric Acid SCHEMBL8597573 | 0.84 | ERBB2 (0.98) | ERBB2EGFRERBB4 | |
| SCHEMBL9910675 | 0.83 | EGFR (0.84) | ERBB2EGFRERBB4 | |
| SCHEMBL8556847 | 0.83 | ERBB2 (1.00) | ERBB2EGFRERBB4KDR | |
| SCHEMBL6768642 | 0.82 | ERBB2 (0.76) | ERBB2EGFRERBB4 | |
| SCHEMBL8560791 | 0.82 | ERBB2 (0.84) | ERBB2EGFRERBB4KDR | |
| Hydrochloric Acid SCHEMBL8596174 | 0.82 | ERBB2 (0.98) | ERBB2EGFRERBB4KDR | |
| Hydrochloric Acid SCHEMBL6767640 | 0.82 | ERBB2 (0.74) | ERBB2EGFRERBB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | claimed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | claimed |
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |