SCHEMBL8560526

SCHEMBL8560526

CNC(=O)c1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Br)c(C)nc34)c2Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 19/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8560523 1.00 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL8567356 0.99 BDKRB2 (1.00) BDKRB2
Hydrochloric Acid SCHEMBL8567359 0.99 BDKRB2 (1.00) BDKRB2
SCHEMBL9077580 0.95 BDKRB2 (0.90) BDKRB2
SCHEMBL9077578 0.95 BDKRB2 (0.90) BDKRB2
SCHEMBL8559424 0.94 BDKRB2 (0.89) BDKRB2
SCHEMBL8559420 0.94 BDKRB2 (0.89) BDKRB2
Hydrochloric Acid SCHEMBL8561787 0.94 BDKRB2 (0.89) BDKRB2
Hydrochloric Acid SCHEMBL8561786 0.94 BDKRB2 (0.89) BDKRB2
SCHEMBL8560814 0.94 BDKRB2 (0.88) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP claimed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US claimed
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed