Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31595897 | 0.85 | HTT (0.58) | HTTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL199906 | 0.85 | HTT (0.58) | HTTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL28342438 | 0.83 | HTT (0.56) | HTTALDH1A1CYP1A2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27672403 | 0.83 | HTT (0.56) | HTTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL1131286 | 0.80 | NCF1 (0.50) | ALDH1A1CYP1A2MEN1KMT2AMAPT | |
| SCHEMBL31498821 | 0.80 | NCF1 (0.50) | ALDH1A1CYP1A2MEN1KMT2AMAPT | |
| SCHEMBL4655065 | 0.79 | HTT (0.45) | HTTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL8617215 | 0.79 | NPC1 (0.46) | HTTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL12386818 | 0.79 | HTT (0.63) | HTTALDH1A1CYP1A2MEN1KMT2A | |
| SCHEMBL11694952 | 0.79 | NPC1 (0.63) | HTTALDH1A1CYP1A2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |