Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 10/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP3A5 | P20815 | 2/20 | 0.39 |
| ▸ | CYP3A7 | P24462 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.39 |
| ▸ | CYP3A43 | Q9HB55 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739261 | 0.73 | MAPT (0.39) | KMT2AMAPTMAPK1LMNAHPGD | |
| SCHEMBL7738544 | 0.72 | MAPT (0.40) | KMT2AMAPTMAPK1LMNAHPGD | |
| SCHEMBL7737740 | 0.72 | MAPT (0.40) | KMT2AMAPTMAPK1LMNAHPGD | |
| SCHEMBL7737941 | 0.72 | MAPT (0.40) | KMT2AMAPTMAPK1LMNAHPGD | |
| SCHEMBL7738515 | 0.72 | MAPT (0.40) | KMT2AMAPTMAPK1LMNAHPGD | |
| SCHEMBL11358872 | 0.72 | CYP2D6 (0.59) | POLBHTR6HTR2ACYP1A2CYP3A4 | |
| SCHEMBL7739394 | 0.71 | MAPT (0.40) | KMT2AMAPTMAPK1LMNAHPGD | |
| SCHEMBL20828122 | 0.71 | POLB (0.60) | POLBHTR6KMT2AHTR2AHRH3 | |
| SCHEMBL17979696 | 0.71 | POLB (0.60) | POLBHTR6KMT2AHTR2AHRH3 | |
| SCHEMBL478235 | 0.71 | POLB (0.60) | POLBHTR6KMT2AHTR2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817842-A | Process for the preparation of epoxides from olefins | ENICHEM S.P.A. (IT) | 1998-10-06 | — | — | US | disclosed |
| EP-0819683-A1 | Process for the preparation of epoxides from olefins | ENICHEM S.p.A. (IT) | 1998-01-21 | — | — | EP | disclosed |