SCHEMBL8561575

SCHEMBL8561575

CC1(OC(N)=O)NCCc2cc(Cl)ccc21

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 5/20 0.40
HTR2C P28335 5/20 0.40
HTR2B P41595 4/20 0.40
SRD5A1 P18405 8/20 0.38
ALDH1A1 P00352 2/20 0.38
MAPT P10636 2/20 0.38
RECQL P46063 2/20 0.38
TDP1 Q9NUW8 2/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP3A4 P08684 1/20 0.38
THRB P10828 1/20 0.38
HPGD P15428 1/20 0.38
ALOX12 P18054 1/20 0.38
CASP1 P29466 1/20 0.38
BLM P54132 1/20 0.38
CASP7 P55210 1/20 0.38
HSD17B10 Q99714 1/20 0.38
PNMT P11086 1/20 0.38
SRD5A2 P31213 2/20 0.37
F7 P08709 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8558452 0.91 HTR2A (0.47) HTR2AHTR2CHTR2BSRD5A1ALDH1A1
SCHEMBL8557120 0.88 ALDH1A1 (0.42) ALDH1A1MAPTRECQLTDP1KDM4E
SCHEMBL9756718 0.81 TDP1 (0.35) HTR2AALDH1A1MAPTRECQLTDP1
SCHEMBL8557048 0.78 ALDH1A1 (0.40) ALDH1A1MAPTRECQLTDP1KDM4E
SCHEMBL8320956 0.72 ALDH1A1 (0.42) HTR2AHTR2CHTR2BSRD5A1ALDH1A1
SCHEMBL9845300 0.68 TDP1 (0.39) HTR2AALDH1A1MAPTRECQLTDP1
Bromide SCHEMBL11392022 0.66 ALDH1A1 (0.47) HTR2AHTR2CHTR2BALDH1A1MAPT
Hydrochloric Acid SCHEMBL11391317 0.66 ALDH1A1 (0.47) HTR2AHTR2CHTR2BALDH1A1MAPT
SCHEMBL20504223 0.65 KDM1A (0.50) ALDH1A1MAPTRECQLTDP1KDM4E
SCHEMBL8318402 0.65 HTR2A (0.48) HTR2AHTR2CHTR2BSRD5A1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0538248-B1 TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYLPYRROLO [2,3-B]INDOLE HOECHST MARION ROUSSEL INC (US) 1998-02-11 EP disclosed
EP-0538248-A4 1994-08-03 EP disclosed
EP-0538248-A1 TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYLPYRROLO [2,3-B]INDOLE HOECHST MARION ROUSSEL, INC. (US) 1993-04-28 EP disclosed
WO-1992000072-A1 TETRAHYDROISOQUINOLINYLCARBAMATES OF 1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYLPYRROLO[2,3-B]INDOLE HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1992-01-09 WO disclosed