SCHEMBL856167

SCHEMBL856167

COC(=O)[C@H]1C(C(=O)Nc2c(F)cc(Br)cc2F)[C@@H]2C=C[C@H]1C21CC1

nearest known ligand 0.58

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FPR2 P25090 20/20 0.58
FPR3 P25089 17/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2683036 1.00 FPR2 (0.58) FPR2FPR3
SCHEMBL856355 0.86 FPR2 (0.63) FPR2FPR3
SCHEMBL2682650 0.86 FPR2 (0.63) FPR2FPR3
SCHEMBL855247 0.85 FPR2 (0.60) FPR2FPR3
SCHEMBL2683402 0.85 FPR2 (0.60) FPR2FPR3
SCHEMBL2681993 0.83 FPR2 (0.50) FPR2FPR3
SCHEMBL856358 0.82 FPR2 (0.59) FPR2FPR3
SCHEMBL2682987 0.82 FPR2 (0.59) FPR2FPR3
SCHEMBL2683064 0.81 FPR2 (0.60) FPR2FPR3
SCHEMBL2682087 0.80 FPR2 (0.72) FPR2FPR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2432760-A1 BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS Actelion Pharmaceuticals Ltd. (CH) 2012-03-28 EP disclosed