Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 12/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 8/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.52 |
| ▸ | BLM | P54132 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL8562089 | 1.00 | ADRB2 (0.52) | ADRB2TDP1KDM4EMAPTHSD17B10 | |
| Oxalic Acid SCHEMBL8560131 | 0.96 | ADRB2 (0.52) | ADRB2TDP1KDM4EMAPTHSD17B10 | |
| Oxalic Acid SCHEMBL8562340 | 0.96 | ADRB2 (0.52) | ADRB2TDP1KDM4EMAPTHSD17B10 | |
| SCHEMBL8563324 | 0.94 | ADRB2 (0.56) | ADRB2TDP1KDM4EMAPTHSD17B10 | |
| SCHEMBL8563319 | 0.94 | ADRB2 (0.56) | ADRB2TDP1KDM4EMAPTHSD17B10 | |
| SCHEMBL8560539 | 0.90 | ADRB2 (0.58) | ADRB2TDP1KDM4EMAPTHSD17B10 | |
| SCHEMBL8560544 | 0.90 | ADRB2 (0.58) | ADRB2TDP1KDM4EMAPTHSD17B10 | |
| Oxalic Acid SCHEMBL8596320 | 0.88 | ADRB2 (0.50) | ADRB2TDP1KDM4EMAPTHSD17B10 | |
| Oxalic Acid SCHEMBL8596317 | 0.88 | ADRB2 (0.50) | ADRB2TDP1KDM4EMAPTHSD17B10 | |
| Oxalic Acid SCHEMBL8596380 | 0.82 | ADRB2 (0.59) | ADRB2TDP1KDM4EMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5775329-A | DERIVATIVES OF NOREPINEPHRINE USED TO STIMULATE EXERCISE STRESS AND ITS EFFECTS ON THE HEART. | GENSIA, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| EP-0833816-A1 | METHODS AND COMPOUNDS FOR DIAGNOSING CORONARY ARTERY DISEASE | GENSIA, INC. (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996040621-A1 | METHODS AND COMPOUNDS FOR DIAGNOSING CORONARY ARTERY DISEASE | GENSIA, INC. (US) | 1996-12-19 | — | — | WO | disclosed |