Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR2 | P25090 | 17/20 | 0.57 |
| ▸ | FPR3 | P25089 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22622484 | 0.86 | FPR2 (0.48) | FPR2FPR3ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL856317 | 0.85 | FPR2 (0.51) | FPR2FPR3ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL856378 | 0.79 | FPR2 (0.66) | FPR2FPR3 | |
| SCHEMBL856527 | 0.78 | FPR2 (0.56) | FPR2FPR3ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL8547143 | 0.78 | FPR2 (0.56) | FPR2FPR3ALDH1A1SMN1; SMN2PKM | |
| SCHEMBL23130050 | 0.75 | FPR2 (0.77) | FPR2FPR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL726568 | 0.75 | FPR2 (1.00) | FPR2FPR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL855346 | 0.74 | FPR2 (0.65) | FPR2FPR3 | |
| SCHEMBL725486 | 0.73 | FPR2 (1.00) | FPR2FPR3ALDH1A1SMN1; SMN2 | |
| SCHEMBL17922785 | 0.70 | FPR2 (0.49) | FPR2FPR3ALDH1A1SMN1; SMN2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432760-A1 | BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010134014-A1 | BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-25 | — | — | WO | disclosed |