Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8559442 | 0.99 | HRH3 (0.52) | HRH3OPRK1CCR3SIGMAR1DRD2 | |
| SCHEMBL8565697 | 0.92 | HRH3 (0.54) | HRH3OPRK1CCR3 | |
| SCHEMBL8557172 | 0.86 | OPRK1 (0.44) | HRH3OPRK1SIGMAR1DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL8564501 | 0.85 | OPRK1 (0.43) | HRH3OPRK1SIGMAR1DRD2HTR2A | |
| SCHEMBL8565619 | 0.85 | OPRK1 (0.49) | OPRK1SIGMAR1 | |
| SCHEMBL8563089 | 0.84 | OPRK1 (0.63) | HRH3OPRK1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8565921 | 0.84 | OPRK1 (0.48) | OPRK1SIGMAR1 | |
| SCHEMBL8559237 | 0.82 | OPRK1 (0.52) | HRH3OPRK1 | |
| SCHEMBL8559450 | 0.81 | OPRK1 (0.51) | HRH3OPRK1 | |
| Hydrochloric Acid SCHEMBL8558023 | 0.81 | OPRK1 (0.51) | HRH3OPRK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |