Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562883 | 1.00 | HSD17B10 (0.38) | HSD17B10HTTBRD4CREBBPHPGD | |
| SCHEMBL8565239 | 1.00 | HSD17B10 (0.38) | HSD17B10HTTBRD4CREBBPHPGD | |
| SCHEMBL8561825 | 0.84 | HPGD (0.42) | HSD17B10HTTBRD4CREBBPHPGD | |
| SCHEMBL8561821 | 0.84 | HPGD (0.42) | HSD17B10HTTBRD4CREBBPHPGD | |
| SCHEMBL8561817 | 0.84 | HPGD (0.42) | HSD17B10HTTBRD4CREBBPHPGD | |
| SCHEMBL8567220 | 0.82 | HSD17B10 (0.44) | HSD17B10HTTBRD4CREBBPMTNR1A | |
| SCHEMBL8567223 | 0.82 | HSD17B10 (0.44) | HSD17B10HTTBRD4CREBBPMTNR1A | |
| SCHEMBL8444707 | 0.82 | HSD17B10 (0.44) | HSD17B10HTTBRD4CREBBPMTNR1A | |
| SCHEMBL2575051 | 0.81 | MAPT (0.43) | HSD17B10HTTBRD4CREBBPHPGD | |
| SCHEMBL8571952 | 0.80 | HSD17B10 (0.38) | HSD17B10HTTBRD4CREBBPHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| CN-1169986-A | 2.9-diamino-and 2-amino-8-carbamoyl-4-hydroxy-aldanoic acid amide derivatives | CIBA GEIGY AG (CH) | 1998-01-14 | — | — | CN | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |