Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561817 | 1.00 | HPGD (0.42) | HPGDGAAMAPTBCHEMTNR1A | |
| SCHEMBL8561821 | 1.00 | HPGD (0.42) | HPGDGAAMAPTBCHEMTNR1A | |
| SCHEMBL8565239 | 0.84 | HSD17B10 (0.38) | HPGDGAAMAPTMTNR1AMTNR1B | |
| SCHEMBL8562883 | 0.84 | HSD17B10 (0.38) | HPGDGAAMAPTMTNR1AMTNR1B | |
| SCHEMBL8562879 | 0.84 | HSD17B10 (0.38) | HPGDGAAMAPTMTNR1AMTNR1B | |
| SCHEMBL8566742 | 0.83 | ALDH1A1 (0.44) | HPGDGAABCHEHSD17B10KDM4E | |
| SCHEMBL2578087 | 0.79 | HSD17B10 (0.38) | HPGDGAAMAPTHSD17B10KDM4E | |
| SCHEMBL8571952 | 0.79 | HSD17B10 (0.38) | HPGDGAAMAPTHSD17B10KDM4E | |
| SCHEMBL8571954 | 0.79 | HSD17B10 (0.38) | HPGDGAAMAPTHSD17B10KDM4E | |
| SCHEMBL8444707 | 0.78 | HSD17B10 (0.44) | MAPTBCHEMTNR1AMTNR1BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |