Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES2 | Q9H7Z7 | 14/20 | 0.57 |
| ▸ | PTGES | O14684 | 4/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208334 | 0.92 | PTGES2 (0.55) | PTGES2PTGESALOX5APMAPTCYP3A4 | |
| SCHEMBL23270837 | 0.90 | PTGES2 (0.64) | PTGES2PTGESALOX5APMAPTCYP3A4 | |
| SCHEMBL30181561 | 0.90 | PTGES2 (0.64) | PTGES2PTGESALOX5APMAPTCYP3A4 | |
| SCHEMBL9047220 | 0.89 | PTGES2 (0.61) | PTGES2PTGESALOX5APMAPTCYP3A4 | |
| SCHEMBL9045434 | 0.88 | PTGES2 (0.61) | PTGES2PTGESALOX5APMAPTCYP3A4 | |
| SCHEMBL9221079 | 0.88 | PTGES2 (0.54) | PTGES2PTGESALOX5APMAPTCYP3A4 | |
| SCHEMBL8561632 | 0.85 | PTGES2 (0.58) | PTGES2PTGESALOX5APMAPTCYP3A4 | |
| SCHEMBL9044180 | 0.83 | PTGES2 (0.80) | PTGES2PTGESALOX5APMAPTCYP3A4 | |
| SCHEMBL9581088 | 0.82 | PTGES2 (0.64) | PTGES2PTGESALOX5APMAPTCYP3A4 | |
| SCHEMBL9581776 | 0.82 | PTGES2 (0.64) | PTGES2PTGESALOX5APMAPTCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691972-B1 | FURO 3,2-b]PYRIDINES AND THIENO 3,2-b]PYRIDINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC (CA) | 1998-07-01 | — | — | EP | disclosed |
| EP-0535925-B1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC (CA) | 1996-04-24 | — | — | EP | disclosed |
| US-5374635-A | Antiinflammatory agents, lipoxygenase inhibitor, antiallergens , cytoprotective agents | MERCK FROSST CANADA, INC. (CA) | 1994-12-20 | — | — | US | disclosed |
| US-5308850-A | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1994-05-03 | — | — | US | disclosed |
| EP-0535925-A1 | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA INC. (CA) | 1993-04-07 | — | — | EP | disclosed |