Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 7/20 | 0.47 |
| ▸ | CNR2 | P34972 | 7/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.39 |
| ▸ | LTB4R2 | Q9NPC1 | 2/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566189 | 0.88 | CNR1 (0.56) | CNR1CNR2LTB4RLTB4R2CYP4F2 | |
| SCHEMBL27545958 | 0.86 | CNR1 (0.62) | CNR1CNR2LTB4RLTB4R2 | |
| SCHEMBL27545957 | 0.86 | CNR1 (0.56) | CNR1CNR2LTB4RLTB4R2CYP4F2 | |
| SCHEMBL8569884 | 0.84 | CNR2 (0.54) | CNR1CNR2LTB4RLTB4R2CYP4F2 | |
| SCHEMBL8567849 | 0.83 | CNR1 (0.51) | CNR1CNR2LTB4RLTB4R2CYP4F2 | |
| SCHEMBL27507369 | 0.82 | CNR1 (0.47) | CNR1CNR2LTB4RLTB4R2CYP4F2 | |
| SCHEMBL6035844 | 0.78 | ALDH1A1 (0.47) | CNR1CNR2CYP4F2CYP4A11ALDH1A1 | |
| SCHEMBL27520483 | 0.77 | CA12 (0.55) | CYP4F2CYP4A11ALDH1A1GAAKDM4E | |
| SCHEMBL27573118 | 0.75 | CNR1 (0.64) | CNR1CNR2LTB4RLTB4R2 | |
| SCHEMBL12610480 | 0.74 | CNR1 (0.47) | CNR1CNR2CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |