Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | UTS2R | Q9UKP6 | 4/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562076 | 0.99 | THRB (0.36) | MAPTTHRBUTS2RHRH3KCNH2 | |
| SCHEMBL8556894 | 0.95 | MAPT (0.35) | MAPTTHRBUTS2RHRH3CHRM2 | |
| SCHEMBL8558697 | 0.94 | HRH3 (0.35) | MAPTTHRBUTS2RHRH3KCNH2 | |
| SCHEMBL8563224 | 0.92 | MAPT (0.36) | MAPTTHRBUTS2RHRH3KCNH2 | |
| SCHEMBL8560472 | 0.91 | THRB (0.36) | MAPTTHRBUTS2RHRH3KCNH2 | |
| SCHEMBL8560733 | 0.88 | MAPT (0.35) | MAPTTHRBUTS2RHRH3OPRK1 | |
| SCHEMBL8562827 | 0.88 | MAPT (0.35) | MAPTTHRBUTS2RHRH3OPRK1 | |
| SCHEMBL8563103 | 0.88 | UTS2R (0.43) | MAPTUTS2RHRH3OPRK1 | |
| SCHEMBL8563095 | 0.88 | HRH3 (0.33) | MAPTUTS2RHRH3KCNH2OPRK1 | |
| SCHEMBL8558229 | 0.87 | CYP2D6 (0.35) | UTS2RHRH3KCNH2OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |