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SCHEMBL8563597

SCHEMBL8563597

Cc1nc2c(OCc3c(Cl)ccc(N(C)C(=O)CNC(=O)COc4ccccc4)c3Cl)cccn2c1Br

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ BDKRB2 P30411 13/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8566090 0.99 BDKRB2 (0.99) BDKRB2
SCHEMBL8565387 0.92 BDKRB2 (0.85) BDKRB2
SCHEMBL8560179 0.91 BDKRB2 (0.85) BDKRB2
SCHEMBL8567110 0.90 BDKRB2 (1.00) BDKRB2
SCHEMBL8558407 0.90 BDKRB2 (0.84) BDKRB2
Hydrochloric Acid SCHEMBL8568396 0.90 BDKRB2 (0.85) BDKRB2
SCHEMBL8566492 0.90 BDKRB2 (0.86) BDKRB2
SCHEMBL8568642 0.90 BDKRB2 (0.88) BDKRB2
SCHEMBL8561456 0.90 BDKRB2 (0.86) BDKRB2
Hydrochloric Acid SCHEMBL8561408 0.90 BDKRB2 (0.84) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 — — EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 — — US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 — — EP disclosed