Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 2/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.57 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4376794 | 0.90 | POLB (0.69) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL29510859 | 0.81 | NOTUM (1.00) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL709869 | 0.81 | NOTUM (1.00) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL4019697 | 0.81 | SMN1; SMN2 (0.79) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL12308329 | 0.81 | NOTUM (0.69) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL6127792 | 0.80 | KDM4E (0.66) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL8623849 | 0.80 | ALDH1A1 (0.65) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL29353444 | 0.80 | SMN1; SMN2 (0.77) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL4291340 | 0.80 | SMN1; SMN2 (0.77) | NOTUMSMN1; SMN2MEN1KMT2ATSHR | |
| SCHEMBL2829456 | 0.80 | SMN1; SMN2 (0.77) | NOTUMSMN1; SMN2MEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| CN-1169986-A | 2.9-diamino-and 2-amino-8-carbamoyl-4-hydroxy-aldanoic acid amide derivatives | CIBA GEIGY AG (CH) | 1998-01-14 | — | — | CN | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |