Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 11/20 | 0.49 |
| ▸ | LTB4R2 | Q9NPC1 | 10/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563541 | 0.91 | NR1H4 (0.48) | LTB4RLTB4R2NR1H4C5AR1ABCB1 | |
| SCHEMBL8568257 | 0.91 | NR1H4 (0.52) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL6757622 | 0.90 | NR1H4 (0.51) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL8563594 | 0.89 | LTB4R (0.48) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL8568097 | 0.89 | LTB4R (0.49) | LTB4RLTB4R2NR1H4C5AR1 | |
| SCHEMBL8563809 | 0.87 | NR1H4 (0.46) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL8562583 | 0.87 | LTB4R (0.50) | LTB4RLTB4R2NR1H4DHODH | |
| SCHEMBL8563732 | 0.85 | NR1H4 (0.49) | LTB4RLTB4R2NR1H4 | |
| SCHEMBL8560557 | 0.85 | LTB4R (0.65) | LTB4RLTB4R2CNR1CNR2 | |
| SCHEMBL8563657 | 0.85 | NR1H4 (0.49) | LTB4RLTB4R2NR1H4C5AR1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |