SCHEMBL8563678

SCHEMBL8563678

Fc1ccc2cc(F)c(F)cc2c1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.62
CYP2A6 P11509 1/20 0.62
BACE1 P56817 1/20 0.43
CASP3 P42574 2/20 0.42
SENP8 Q96LD8 2/20 0.42
SENP7 Q9BQF6 2/20 0.42
SENP6 Q9GZR1 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
CA3 P07451 1/20 0.42
CA6 P23280 1/20 0.42
CA5A P35218 1/20 0.42
CA9 Q16790 1/20 0.42
CA14 Q9ULX7 1/20 0.42
CA5B Q9Y2D0 1/20 0.42
ALDH1A1 P00352 1/20 0.42
AHR P35869 2/20 0.41
SLC6A4 P31645 4/20 0.37
SLC6A3 Q01959 4/20 0.37
CES2 O00748 2/20 0.37
CES1 P23141 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3828830 0.88 CYP1A2 (0.68) CYP1A2CYP2A6BACE1CASP3SENP8
SCHEMBL11303205 0.88 CYP1A2 (0.68) CYP1A2CYP2A6BACE1CASP3SENP8
SCHEMBL30366405 0.87 CYP1A2 (0.77) CYP1A2CYP2A6BACE1CASP3SENP8
SCHEMBL6562601 0.87 CYP1A2 (0.77) CYP1A2CYP2A6BACE1CASP3SENP8
SCHEMBL29936739 0.84 CYP1A2 (0.72) CYP1A2CYP2A6BACE1CASP3SENP8
SCHEMBL6564751 0.84 CYP1A2 (0.72) CYP1A2CYP2A6BACE1CASP3SENP8
SCHEMBL8141016 0.83 CYP1A2 (0.50) CYP1A2CYP2A6BACE1CASP3SENP8
SCHEMBL20967265 0.83 CYP1A2 (0.50) CYP1A2CYP2A6BACE1CASP3SENP8
SCHEMBL8789837 0.80 CYP2A6 (0.84) CYP1A2CYP2A6BACE1CASP3SENP8
SCHEMBL1310942 0.80 CYP2A6 (0.84) CYP1A2CYP2A6BACE1CASP3SENP8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5756730-A Process for preparing analgesic compounds SANKYO COMPANY, LIMITED (JP) 1998-05-26 US disclosed
US-5656758-A AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND SANKYO COMPANY, LIMITED (JP) 1997-08-12 US disclosed
US-5512567-A KAPPA-RECEPTOR AGONISTS SANKYO COMPANY, LIMITED (JP) 1996-04-30 US disclosed
US-5270327-A Piperidine derivatives SANKYO COMPANY, LIMITED (JP) 1993-12-14 US disclosed
EP-0356247-B1 ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES Sankyo Company Limited (JP) 1993-03-17 EP disclosed
US-5021413-A Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them SANKYO COMPANY LIMITED (JP) 1991-06-04 US disclosed
EP-0356247-A1 Analgesic carboxylic acid amide derivatives Sankyo Company Limited (JP) 1990-02-28 EP disclosed