Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7820039 | 1.00 | KDM4E (0.56) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL8563782 | 1.00 | KDM4E (0.56) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL8444707 | 0.84 | HSD17B10 (0.44) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL8567220 | 0.84 | HSD17B10 (0.44) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL8567223 | 0.84 | HSD17B10 (0.44) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL31343808 | 0.80 | KDM4E (0.41) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL8561825 | 0.78 | HPGD (0.42) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL8561821 | 0.78 | HPGD (0.42) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL8561817 | 0.78 | HPGD (0.42) | KDM4EHSD17B10TSHRMAPTALDH1A1 | |
| SCHEMBL2575051 | 0.77 | MAPT (0.43) | KDM4EHSD17B10TSHRMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719141-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1998-02-17 | — | — | US | disclosed |
| EP-0702004-A2 | 2,9-diamino- and 2-amino-8-carbamoyl-4-hydroxy-alkanoic acid amid derivatives | CIBA-GEIGY AG (CH) | 1996-03-20 | — | — | EP | disclosed |