⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2441916 | 0.79 | — | — | |
| Ammonia Solution, Strong SCHEMBL10990376 | 0.77 | — | — | |
| SCHEMBL7227356 | 0.75 | — | — | |
| SCHEMBL68724 | 0.75 | TSHR (0.44) | — | |
| SCHEMBL9861086 | 0.71 | — | — | |
| SCHEMBL724826 | 0.71 | — | — | |
| SCHEMBL4982398 | 0.71 | — | — | |
| SCHEMBL10186900 | 0.71 | — | — | |
| Nitroacetic Acid SCHEMBL16673169 | 0.69 | LMNA (0.46) | — | |
| Nitroacetic Acid SCHEMBL953175 | 0.69 | LMNA (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1056140-C | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 2000-09-06 | — | — | CN | disclosed |
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| CN-1095374-A | Biphenyl derivatives, their preparation and they are in the application for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1994-11-23 | — | — | CN | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |