Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 8/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TOP2A | P11388 | 2/20 | 0.41 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563927 | 1.00 | KCNH2 (0.50) | KCNH2HRH3CACNA1FPOLBMAPK1 | |
| SCHEMBL9422758 | 0.92 | KCNH2 (0.49) | KCNH2HRH3CACNA1FPOLBMAPK1 | |
| SCHEMBL9422761 | 0.92 | KCNH2 (0.49) | KCNH2HRH3CACNA1FPOLBMAPK1 | |
| SCHEMBL8568909 | 0.89 | KCNH2 (0.54) | KCNH2HRH3CACNA1FPOLBMAPK1 | |
| SCHEMBL8568906 | 0.89 | KCNH2 (0.54) | KCNH2HRH3CACNA1FPOLBMAPK1 | |
| SCHEMBL8573733 | 0.86 | KCNH2 (0.56) | KCNH2HRH3CACNA1FPOLBMAPK1 | |
| SCHEMBL8566245 | 0.86 | KCNH2 (0.56) | KCNH2HRH3CACNA1FPOLBMAPK1 | |
| SCHEMBL8565922 | 0.85 | KDM4E (0.60) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL8565928 | 0.85 | KDM4E (0.60) | KDM4EALDH1A1LMNAHPGDHSD17B10 | |
| SCHEMBL8563931 | 0.83 | KCNH2 (0.47) | KCNH2HRH3CACNA1FPOLBMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559752-B1 | OPTICAL ISOMERS OF 7- 3-(1,1-DIALKYLMETHYL-1-AMINO-1-PYRROLIDINYL]-QUINOLONES AND NAPHTHYRIDONES AS ANTIBACTERIAL AGENTS | WARNER LAMBERT CO (US) | 1998-01-28 | — | — | EP | disclosed |
| US-5278317-A | Aminomethylpyrrole | WARNER-LAMBERT COMPANY (US) | 1994-01-11 | — | — | US | disclosed |
| EP-0559752-A1 | OPTICAL ISOMERS OF 7- 3-(1,1-DIALKYLMETHYL-1-AMINO-1-PYRROLIDINYL]-QUINOLONES AND NAPHTHYRIDONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5157128-A | Antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1992-10-20 | — | — | US | disclosed |
| WO-1992009597-A1 | OPTICAL ISOMERS OF 7-[3-(1,1-DIALKYLMETHYL-1-AMINO-1-PYRROLIDINYL]-QUINOLONES AND NAPHTHYRIDONES AS ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-06-11 | — | — | WO | disclosed |