Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 1/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | SI | P14410 | 1/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.49 |
| ▸ | PTGES | O14684 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951540 | 0.78 | ALDH1A1 (0.61) | CBFBADORA3KDM4EALDH1A1NPC1 | |
| SCHEMBL22955432 | 0.77 | NPC1 (0.61) | CBFBKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL29824605 | 0.75 | NPC1 (0.49) | CBFBGAAPTGESHTTKDM4E | |
| SCHEMBL2951537 | 0.75 | NPC1 (0.49) | CBFBGAAPTGESHTTKDM4E | |
| SCHEMBL17829671 | 0.72 | GUSB (0.58) | PTGESPARP1GUSBTYMPPIM1 | |
| SCHEMBL124230 | 0.72 | CBFB (1.00) | CBFBADORA3ADORA1KDM4EALDH1A1 | |
| SCHEMBL1133803 | 0.72 | NPC1 (0.52) | GAAMGAMSIMGAM2PTGES | |
| SCHEMBL5201397 | 0.72 | MGAM (0.68) | CBFBADORA3ADORA1GAAMGAM | |
| SCHEMBL784353 | 0.70 | NPC1 (0.66) | GAAHTTKDM4EALDH1A1NPC1 | |
| SCHEMBL29825055 | 0.70 | NPC1 (0.66) | GAAHTTKDM4EALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821675-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033176-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-10-24 | — | — | WO | disclosed |