Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 9/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | PNP | P00491 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304796 | 0.73 | — | — | |
| SCHEMBL2423141 | 0.68 | KMT2A (0.38) | RAB9A | |
| SCHEMBL6449281 | 0.68 | HRH4 (0.44) | HRH4HTR3ADAOHRH3CYP11B2 | |
| SCHEMBL28853 | 0.68 | HRH4 (0.41) | HRH4HTR3ADAOHRH3CYP11B2 | |
| SCHEMBL7854169 | 0.67 | HRH4 (0.34) | HRH4ALDH1A1 | |
| SCHEMBL7845033 | 0.67 | HRH4 (0.34) | HRH4ALDH1A1 | |
| SCHEMBL956706 | 0.67 | CYP11B2 (0.39) | HRH4HTR3ADAOHRH3CYP11B2 | |
| SCHEMBL8562907 | 0.67 | HRH4 (0.36) | HRH4HTR3ADAOHRH3CYP11B2 | |
| SCHEMBL2425560 | 0.66 | KMT2A (0.35) | RAB9A | |
| SCHEMBL15414991 | 0.66 | HRH4 (0.36) | HRH4HTR3ADAOHRH3CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821675-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033176-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-10-24 | — | — | WO | disclosed |