Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | BID | P55957 | 3/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.40 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | EP300 | Q09472 | 1/20 | 0.40 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.40 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2775024 | 0.98 | TLR8 (0.43) | TLR8HTR2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1193690 | 0.93 | KCNH2 (0.50) | TLR8HTR2ALIPGKCNH2ALOX5 | |
| SCHEMBL15345445 | 0.90 | TLR8 (0.42) | TLR8HTR2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL18378266 | 0.86 | TLR8 (0.39) | TLR8HTR2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL25325280 | 0.86 | TLR8 (0.39) | TLR8HTR2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL27937846 | 0.83 | CYP3A4 (0.40) | TLR8HTR2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15345387 | 0.83 | LIPG (0.46) | TLR8HTR2ALIPGKCNH2ALOX5 | |
| SCHEMBL23458364 | 0.83 | KDM4E (0.57) | TLR8HTR2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL29861903 | 0.83 | KDM4E (0.57) | TLR8HTR2ACYP3A4CYP2D6CYP2C9 | |
| SCHEMBL15345347 | 0.83 | LIPG (0.46) | TLR8HTR2ALIPGKCNH2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| CN-1036004-C | Process for preparing analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1997-10-01 | — | — | CN | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| CN-1034731-C | Process for preparing analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1997-04-30 | — | — | CN | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| CN-1030450-C | Preparation of analgesic carboxylic acid amides derivative | SANKYO CO (JP) | 1995-12-06 | — | — | CN | disclosed |
| CN-1079741-A | The preparation method of analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-12-22 | — | — | CN | disclosed |
| CN-1079740-A | The preparation method of analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-12-22 | — | — | CN | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| CN-1078461-A | The preparation method of analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-11-17 | — | — | CN | disclosed |
| CN-1022185-C | Process for preparing analgesic carboxylic acid amide derivatives | SANKYO CO (JP) | 1993-09-22 | — | — | CN | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| CN-1040791-A | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | SANKYO CO (JP) | 1990-03-28 | — | — | CN | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |