SCHEMBL8564258

SCHEMBL8564258

CCCCCCCCOc1ccc(C(=O)Oc2ccc(OCC(C)CC)cc2)cc1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.66
LMNA P02545 3/20 0.66
NFKB1 P19838 3/20 0.66
NFKB2 Q00653 3/20 0.66
RELA Q04206 3/20 0.66
SMN1; SMN2 Q16637 2/20 0.66
CYP1A2 P05177 1/20 0.64
CYP3A4 P08684 1/20 0.64
CYP2D6 P10635 1/20 0.64
CYP2C9 P11712 1/20 0.64
CYP2C19 P33261 1/20 0.64
PLA2G4B P0C869 5/20 0.59
MAPT P10636 2/20 0.57
POLB P06746 1/20 0.57
TP53 P04637 1/20 0.57
TSHR P16473 1/20 0.57
PRSS1 P07477 1/20 0.56
ACR P10323 1/20 0.56
KMT2A Q03164 2/20 0.55
RARB P10826 3/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10621463 1.00 NPC1 (0.66) NPC1LMNANFKB1NFKB2RELA
SCHEMBL11656366 1.00 NPC1 (0.66) NPC1LMNANFKB1NFKB2RELA
SCHEMBL10624408 1.00 NPC1 (0.66) NPC1LMNANFKB1NFKB2RELA
SCHEMBL9711808 1.00 NPC1 (0.66) NPC1LMNANFKB1NFKB2RELA
SCHEMBL8642648 1.00 NPC1 (0.66) NPC1LMNANFKB1NFKB2RELA
SCHEMBL9711812 1.00 NPC1 (0.66) NPC1LMNANFKB1NFKB2RELA
SCHEMBL10553827 1.00 NPC1 (0.66) NPC1LMNANFKB1NFKB2RELA
SCHEMBL8533886 0.96 NPC1 (0.62) NPC1LMNANFKB1NFKB2RELA
SCHEMBL10617383 0.96 NPC1 (0.62) NPC1LMNANFKB1NFKB2RELA
SCHEMBL9063697 0.94 NPC1 (0.59) NPC1LMNANFKB1NFKB2RELA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5746939-A COOLING FROM CHOLESTERIC PHASE TO CHIRAL SMECTIC PHASE; DISPLAY AND DRIVING CANON KABUSHIKI KAISHA (JP) 1998-05-05 US disclosed
US-5726460-A Liquid crystal device CANON KABUSHIKI KAISHA (JP) 1998-03-10 US disclosed
US-5724114-A Liquid crystal device with composition containing optically active material and material showing smectic, smectic A and chiral smectic C phases upon temperature decrease CANON KABUSHIKI KAISHA (JP) 1998-03-03 US disclosed
US-5671033-A Liquid crystal device having mixture of cholesteric and smectic liquid crystals and alignment treatment on only one substrate CANON KABUSHIKI KAISHA (JP) 1997-09-23 US disclosed
US-5648830-A Liquid crystal device having composition of at least two smectic compounds and one cholesteric compound CANON KABUSHIKI KAISHA (JP) 1997-07-15 US disclosed
US-5604614-A Liquid crystal device with one liquid crystal showing a cholesteric phase and one showing a chiral smectic phase CANON KABUSHIKI KAISHA (JP) 1997-02-18 US disclosed
US-5592315-A Liquid crystal device and liquid crystal apparatus CANON KABUSHIKI KAISHA (JP) 1997-01-07 US disclosed
EP-0348939-B1 Method of orienting liquid crystal optical device and apparatus usable for the method IDEMITSU KOSAN CO (JP) 1995-02-15 EP disclosed
US-5332521-A Ferroelectric liquid crystal composition, liquid crystal optical device produced by using the ferroelectric liquid crystal composition, and method of producing the liquid crystal optical device IDEMITSU KOSAN CO., LTD. (JP) 1994-07-26 US disclosed
EP-0276864-B1 Electro-optical modulation device CANON KK (JP) 1994-07-13 EP disclosed
EP-0309870-A2 Liquid crystalline compounds containing the bicyclo[2,2,2]-octane ring and the phenylisothiocyanate group, their manufacturing and liquid crystalline mixtures containing same Wojskowa Akademia Techniczna (PL) 1989-04-05 EP disclosed
US-4818078-A Ferroelectric liquid crystal optical modulation device and driving method therefor for gray scale display CANON KABUSHIKI KAISHA (JP) 1989-04-04 US disclosed
US-4815823-A Electro-optical device with plural low resistive portions on each high resistive electrode CANON KABUSHIKI KAISHA (JP) 1989-03-28 US disclosed
US-4802744-A Optical modulation apparatus CANON KABUSHIKI KAISHA (JP) 1989-02-07 US disclosed
EP-0296571-A2 Method of producing a liquid crystal optical element IDEMITSU KOSAN COMPANY LIMITED (JP) 1988-12-28 EP disclosed
US-4747671-A Ferroelectric optical modulation device and driving method therefor wherein electrode has delaying function CANON KABUSHIKI KAISHA (JP) 1988-05-31 US disclosed
EP-0228557-A2 Optical modulation device and driving method therefor CANON KABUSHIKI KAISHA (JP) 1987-07-15 EP disclosed
EP-0224243-A2 Optical modulation device and driving method therefor CANON KABUSHIKI KAISHA (JP) 1987-06-03 EP disclosed
US-4639089-A Liquid crystal device CANON KABUSHIKI KAISHA (JP) 1987-01-27 US disclosed
EP-0160302-A2 Ferroelectric liquid crystal cell HITACHI, LTD. (JP) 1985-11-06 EP disclosed